Effect of Foreign Protein on Hamsters
نویسنده
چکیده
I N PREVIOUS STUDIES on the anemia of malignancy, a three-way relationship was noted between tumor growth, splenomegaly, and the development of anemia in the tumor-bearing hamster.1’2 It was further shown that the anemia and splenomegaly were in fact related to the progressive increase in the amount of necrotic tissue within the growing tumor.’ In subsequent studies it was found that anemia and splenomegaly could be produced by the daily injection of a sterile, cell-free saline extract of the necrotic portion of the tumor.3 Extracts of hamster tumor were also found to affect erythrocytes in vitro, resulting in hemolysis4 or agglutination. Microscopic examination of the enlarged spleens in these experimental animals revealed reticuloendothelial cell hyperplasia, plasmacytosis and hemosiderosis as well as extramedullary hematopoiesis.2’6 The increased hemosiderin indicated that abnormal splenic hemolysis was present, an interpretation confirmed by studies with radioactive chromium,78 while the plasma cell proliferation suggested the presence of an antibody response to some antigen. It was thought that the antigenic stimulus in these animals might have been furnished by altered or “foreign” protein resulting from the necrosis of tumor tissue. A foreign protein was therefore injected into normal hamsters in an attempt to reproduce the hematologic and pathologic findings seen in the tumorbearing animals. In addition, since the anti-hamster serum erythroagglutination reaction was shown to be positive in a high proportion of tumor-bearing hamsters,9 the effect of foreign protein on the development of this erythrocyte reaction was also studied.
منابع مشابه
Kiwifruit effect on adipose tissue cell size and cholesteryl ester transfer protein gene expression in high-fat diet fed Golden Syrian hamsters
Objective: The effects of kiwifruit on the histology and cell size of adipose tissue in hyperlipidemic models have not yet been reported. Therefore, this study aimed to investigate the effect of kiwifruit on the adipose tissue cell size and activity as well as the gene expression of cholesteryl ester transfer protein (CETP) in high-fat diet (HFD...
متن کاملEffect of laser irradiation on the progression of skin cancer using carcinogen among hamsters
Introduction: Skin cancer has been increased day by day, but it can be cured if it diagnosed early. After reviewing the scientific literature about 980 nm diode laser, and its multiple advantages on skin diseases. We studied in this paper the effectiveness of this type of laser on the progression of skin cancer among hamsters which were exposed to carcinogen on the bac...
متن کاملThe effect of foreign protein on the blood and reticuloendothelial system of the hamster.
I N PREVIOUS STUDIES on the anemia of malignancy, a three-way relationship was noted between tumor growth, splenomegaly, and the development of anemia in the tumor-bearing hamster.1’2 It was further shown that the anemia and splenomegaly were in fact related to the progressive increase in the amount of necrotic tissue within the growing tumor.’ In subsequent studies it was found that anemia and...
متن کاملThe Effect of Concomitant Ethanol and Opium Consumption on Lipid Profiles and Atherosclerosis in Golden Syrian Hamster’s Aorta
Background: Cardiovascular disease (CVD) is the main cause of mortality in the world and is normally argued as the third cause of all mortalities. Opium and alcohol every day consumption can cause people to have many health problems. The present study aimed to assess the effect of ethanol and opium consumption on lipid profiles and atherosclerosis in aorta. Methods: Twenty four male golden Syri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005